Publications by authors named "W John Gray"
Assessing mental health transition readiness in youth with medical conditions.
Health Care Transit
November 2024
Purpose: Many youth with medical conditions also have co-occurring mental health concerns. Limited attention has been given to the mental health transition needs of these youth. We explore bringing transition readiness assessment into the mental health care of youth with co-occurring disorders.
View Article and Find Full Text PDFBackground: Atrial fibrillation (AF) is a recognized risk factor for mortality after transcatheter aortic valve replacement for severe aortic stenosis, but the impact of different types of AF on clinical outcomes remains unclear.
Methods: This retrospective study included 982 patients divided into 3 groups: no AF, paroxysmal AF, and nonparoxysmal AF (persistent or permanent). Clinical outcomes were analyzed using inverse probability weighting and multivariate models.
Article Synopsis
- The study aimed to assess how a community diabetes specialist nurse (cDSN) collaborating with district nurses (DNs) could improve insulin therapy management and optimize patient care.
- The research involved monitoring 148 patients before and after implementing the intervention, focusing on hypoglycaemic and hyperglycaemic events and overall DN workload.
- Results showed a significant decrease in both types of events, reduced DN visits, and substantial cost savings of £1.9 million, suggesting the intervention's effectiveness and the potential for broader application in other areas.
Loss of proteostasis is a hallmark of aging and Alzheimer disease (AD). We identify β-hydroxybutyrate (βHB), a ketone body, as a regulator of protein solubility. βHB primarily provides ATP substrate during periods of reduced glucose availability, and regulates other cellular processes through protein interactions.
View Article and Find Full Text PDFArticle Synopsis
- Percutaneous transluminal angioplasty (PTA) for peripheral artery disease often results in vascular dissections, increasing the need for additional interventions (target lesion revascularization or TLR).
- A study using a decision-analytic model analyzed the clinical outcomes, costs, and quality of life impacts of using the Tack Endovascular System versus the standard PTA approach, showing lower TLR rates with the Tack-supported strategy.
- The results suggest that focal stenting (using Tack) is cost-effective for non-severe dissections and may even save costs for severe cases while improving patient quality of life, highlighting potential economic benefits in managing dissections post-PTA.