Publications by authors named "W Jensen"
The most characteristic feature of the human electroencephalogram is the peak alpha frequency (PAF). While PAF has been proposed as a biomarker in several diseases and disorders, the disease mechanisms modulating PAF, as well as its physiological substrates, remain elusive. This has partly been due to challenges related to experimental manipulation and invasive procedures in human neuroscience, as well as the scarcity of animal models where PAF is consistently present in resting-state.
View Article and Find Full Text PDFMicro-electrocorticography (µECoG) electrodes have emerged to balance the trade-off between invasiveness and signal quality in brain recordings. However, its large-scale applicability is still hindered by a lack of comparative studies assessing the relationship between ECoG and traditional recording methods such as penetrating electrodes. This study aimed to compare somatosensory evoked potentials (SEPs) through the lenses of a µECoG and an intracortical microelectrode array (MEA).
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- This study examined how nerve injuries affect brain activity, specifically looking at hyperexcitability in the primary somatosensory cortex (S1) using a pig model.
- Researchers recorded neuron activity with a multielectrode array to see how stimulating injured versus uninjured nerves changed brain responses.
- The findings indicated that following nerve injury, there was a significant increase in excitability, particularly in cortical layer III, highlighting its key role in brain activity changes post-injury.
Article Synopsis
- The study aimed to create a long-term pain model using long-term potentiation in pigs to better understand pain mechanisms.
- Researchers recorded brain activity in pigs before, during, and after stimulating the ulnar nerve with high-frequency stimulation (HFS) while also measuring their sensitivity to pain.
- Results showed that mechanical sensitivity increased significantly after HFS and correlated with changes in brain activity, suggesting that the pig model closely mimics human pain conditions.
Article Synopsis
- The study aimed to track the development of ischemic stroke in pigs using intracortical recordings for high-resolution feedback on neural function, which could help in optimizing drug treatments.
- Micro-electrode arrays were implanted into the pigs’ brains, and ischemic stroke was induced through a specific chemical injection, with neural responses measured continuously over time.
- Results showed a significant decrease in cortical excitability after stroke, and the findings suggest that this pig model can bridge the gap between rodent studies and human applications for developing neuroprotective therapies.