Publications by authors named "W Jeffrey Humphries"
Background: The EXCELLENT registry aimed to evaluate the effectiveness of the EMBOTRAP Revascularization Device in an all-comer population in a real-world setting, with a focus on the composition of retrieved clots.
Methods: EXCELLENT is a prospective, global registry of patients with acute ischemic stroke treated with EMBOTRAP as the first-line mechanical thrombectomy device conducted at 34 sites (25 sites contributing clot) from September 2018 to March 2021, utilizing core imaging and central histology laboratories blinded to clinical data, independent 90-day modified Rankin Scale assessment and Clinical Events Committee.
Results: After screening 3799 patients, a total of 997 subjects (mean age, 70.
Article Synopsis
- Studies during the COVID-19 pandemic suggest a link between COVID-19 and an increased risk of acute ischemic stroke, particularly in cases of large vessel occlusion (LVO).
- The research involved analyzing blood clots from COVID-19 patients who underwent mechanical thrombectomy and comparing their characteristics with those of a control group.
- Results showed higher levels of C-reactive protein (CRP) and von Willebrand factor (vWF) in COVID-19-positive patients, indicating that systemic inflammation and endothelial injury may play significant roles in clot formation for these individuals.
Background: Although empiric treatment of urinary tract colonized patients remains a frequent practice in neurosurgery, the value of this practice remains debatable.
Objective: To analyze the effect of screening and treatment of bacteriuria on surgical site infections, incidence of Clostridium difficile, and mortality in neurosurgical trauma patients.
Methods: Database queries and direct patient chart reviews were used to gather patient chart data.
We have characterized the expression and secretion of the acute kidney injury (AKI) biomarkers insulin-like growth factor binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinases-2 (TIMP-2) in human kidney epithelial cells in primary cell culture and tissue. We established cell culture model systems of primary kidney cells of proximal and distal tubule origin and observed that both proteins are indeed expressed and secreted in both tubule cell types in vitro. However, TIMP-2 is both expressed and secreted preferentially by cells of distal tubule origin, while IGFBP7 is equally expressed across tubule cell types yet preferentially secreted by cells of proximal tubule origin.
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