Publications by authors named "W Janni"
Article Synopsis
- * The Cardiac Health in Breast Cancer study aims to evaluate how a structured exercise program impacts cardiac health in 48 females undergoing cardiotoxic cancer therapies.
- * Participants will be divided into an intervention group receiving high-intensity training and a control group following general activity guidelines, with a focus on measuring changes in cardiac function and overall well-being over 12 months.
Background: The current standard for the preoperative marking of non-palpable breast lesions is wire guided localization (WGL) which is associated with logistical efforts and patient discomfort. Non-radioactive seeds (NRS) recently challenged the use of WGL; but do they provide a better alternative from a logistical and environmental perspective?
Methods: WGL standard was compared with NRS available in Germany: Magseed®, Pintuition®, SAVI SCOUT ® and LOCalizer™ on a logistical and carbon-footprinting basis. In the logistical analysis the number of patient contacts with the healthcare system for lesion localization/removal and the number of breast punctures were evaluated in two different clinical scenarios (primary surgery and secondary surgery after neoadjuvant treatment).
Background: Although adequate physical activity has been shown to be beneficial in early breast cancer, evidence in metastatic breast cancer is sparse and contradictory, which could be related to distinct effects of physical activity on the different molecular cancer subtypes. Therefore, we here evaluated the effect of physical activity on progression-free and overall survival (PFS, OS) in metastatic breast cancer, specifically looking at molecular subtypes.
Methods: International Physical Activity Questionnaire (IPAQ) questionnaires, filled out by patients enrolled in the prospective PRAEGNANT registry (NCT02338167; n = 1,270) were used to calculate metabolic equivalent task (MET) minutes, which were subsequently categorized into low (n = 138), moderate (n = 995) or high IPAQ categories (n = 137).
Article Synopsis
- - The study investigates the impact of the Restifem® pessary on pelvic floor function in postpartum women, evaluating its effectiveness as both a preventive and therapeutic device from 6 weeks to 12 months after delivery.
- - 857 women participated, with 137 using the pessary and 133 not; findings revealed that pessary users experienced significantly worse pelvic floor function initially but showed greater improvement in scores related to bladder and pelvic organ prolapse over time.
- - The results suggest that using the pessary contributes to improved recovery of pelvic floor function, particularly for women experiencing higher levels of dysfunction postpartum, while also highlighting the study's legitimacy through registration in a clinical trials database.