One clinic visit for pre-exposure rabies vaccination (a preliminary one year study).

We performed an abbreviated prospective study of rabies pre-exposure (PREP) vaccination in 109 volunteers. Group 1, the control group, received the conventional 3 intradermal injections on days 0, 7 and 21. Group 2 received one rabies vaccine injection (0.

A 4‐site, single‐visit intradermal postexposure prophylaxis regimen for previously vaccinated patients: experiences with >5000 patients.

We previously demonstrated that 4‐site, intradermal, single‐visit rabies booster vaccination provides immunogenicity greater than that provided by the standard 2‐booster, 2‐visit regimen. The regimen has been routinely used in 5116 patients since 1998 without any treatment failure. It is not only effective but also saves vaccine costs and transportation expenses and improves compliance.

Common dilemmas in managing rabies exposed subjects.

Health care staff managing rabies exposures in a canine endemic or epidemic environments are often faced with having to make treatment decisions where there are no firm guidelines from WHO or local public health authorities. We have made an attempt to identify several common events that presented to a busy animal bite clinic in a rabies endemic country. Leading experts in this field have been queried about their management opinions in such situtions.

Is injecting a finger with rabies immunoglobulin dangerous?

Treating potentially rabies virus infected wounds requires the injection of rabies immunoglobulin into and around the wounds, followed by vaccination with an approved tissue culture rabies vaccine. A significant number of such bite wounds involves fingers where there is little space for expansion. Injecting immunoglobulin into such areas under pressure may induce a compartment syndrome caused by compromising circulation.