Evaluation of surgical effects is often done using simple cadaver experimentation. This study uses a robotic testbed to estimate the best-case clinical outcomes of flexor tendon shortening during repair surgery on cadaver hands. Nine fresh-frozen cadaver subjects were connected to an extrinsic index finger robotic muscle testbed and measurement system.
View Article and Find Full Text PDFBackground: Unfractionated heparin infusions are commonly used in microvascular surgery to prevent microvascular thrombosis. Previously, fixed-dose heparin infusions were believed to provide sufficient venous thromboembolism (VTE) prophylaxis; however, we now know that this practice is inadequate for the majority of patients. Anti-factor Xa (aFXa) level is a measure of unfractionated heparin efficacy and safety.
View Article and Find Full Text PDFBackground: The accepted "one-size-fits-all" dose strategy for prophylactic enoxaparin may not optimize the medication's risks and benefits after surgical procedures. The authors hypothesized that weight-based administration might improve the pharmacokinetics of prophylactic enoxaparin when compared to fixed-dose administration.
Methods: The FIxed or Variable Enoxaparin (FIVE) trial was a randomized, double-blind trial that compared the pharmacokinetic and clinical outcomes of patients assigned randomly to postoperative venous thromboembolism prophylaxis using enoxaparin 40 mg twice daily or enoxaparin 0.