Publications by authors named "W J Reeves"
Acute kidney injury (AKI) increases mortality risk and predisposes individuals to chronic kidney disease. Metabolic pathways play a crucial role in AKI pathophysiology. Here, we investigate the potential of methylthioadenosine phosphorylase (MTAP) inhibition as a novel renoprotective strategy in AKI.
View Article and Find Full Text PDFBackground: Studies using functional magnetic resonance imaging (fMRI) broadly require a method of parcellating the brain into regions of interest (ROIs). Parcellations can be based on standardized brain anatomy, such as the Montreal Neurological Institute's (MNI) 152 atlas, or an individual's functional activity patterns, such as the Personode software.
New Method: This work outlines and tests the independent component analysis (ICA)-based parcellation algorithm (IPA) when applied to a hypertension study (n = 48) that uses the independent components (ICs) output from group ICA (gICA) to build ROIs which are ideally spatially consistent and functionally homogeneous.
Abnormal autophagy regulation is implicated in lupus and other autoimmune diseases. We investigated autophagy in the murine pristane-induced lupus model. Pristane causes monocyte/macrophage-mediated endoplasmic reticulum (ER) stress in lung endothelial cells and diffuse alveolar hemorrhage (DAH) indistinguishable from DAH in lupus patients.
View Article and Find Full Text PDFArticle Synopsis
- - Sjögren's disease (SD) is an autoimmune condition linked to specific autoantibodies, and a case study showed that a previously healthy individual developed SD after primary Epstein-Barr virus (EBV) infection, resulting in multiple autoantibody productions.
- - Researchers examined immune responses to various autoantigens and found that anti-Ro52 and anti-Ro60 autoantibodies started to appear shortly after EBV infection, with levels continuing to rise alongside other antibodies long after the initial infection.
- - The study concludes that EBV infection can trigger specific autoantibody responses through different mechanisms, and it notes that some healthy individuals can produce certain autoantibodies independently of the EBV response.
Invasive species are a threat to ecosystems worldwide, but determining if a species is adventive or native is not always straightforward. The black flies that inhabit the Galapagos Islands, long known as Simulium ochraceum, are blood-feeding pests of humans and livestock. They first came to the attention of residents in 1989, suggesting a recent arrival.
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