Publications by authors named "W J Powell"

Police crash reports have traditionally been the primary data source for research and development projects aimed at improving traffic safety. However, there are important limitations of such data, particularly the relative infrequency of crashes on a site-by-site basis in many contexts. Crash analyses often require multiple years of data and the use of such data for short-term evaluations creates challenges.

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Article Synopsis
  • * Researchers synthesized a Tau segment with various PTMs and observed that these modifications generally hinder Tau's assembly into PHFs, with acetylation showing variable effects, and phosphorylation consistently reducing aggregation.
  • * The findings emphasize that PTMs located outside the rigid core of Tau filaments are crucial for initiating PHF formation, illustrating the complex role of these modifications in influencing Tau aggregation dynamics.
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The first 8000 days of life, from birth to adulthood, encompasses critical phases that shape a child's health and development. While global health efforts have focused on the first 1000 days, the next 7000 days (ages 2-21) are equally vital, especially concerning the unmet burden of surgical conditions in low- and middle-income countries (LMICs). Approximately 1.

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The changing field of academic medicine presents unique challenges for physician-scientists, who intricately weave the complexities of research and patient care. These challenges have significantly lengthened the time needed for scientific discoveries to be applied in clinical practice. In response to these escalating demands, the training trajectory for physician-scientists has notably expanded over recent decades.

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