Publications by authors named "W J Lynch"
Background: The use of telehealth has grown exponentially since the COVID-19 pandemic. The safety of an initial telehealth preoperative evaluation for patients undergoing general thoracic procedures is unknown.
Methods: We retrospectively reviewed all patients who underwent a general thoracic surgical procedure at our academic tertiary care institution from January 2021 to December 2022.
Background: Donor stagnation and modification of lung allocation scores has resulted in a higher acuity of patient presentation prior to lung transplantation. Extracorporeal membrane oxygenation (ECMO) has been utilized as a bridge to lung transplant (BTT) although the effect of cannulation strategy on outcomes has not been well investigated. We sought to analyze contemporary data on ECMO BTT utilizing a large, international registry of patients.
View Article and Find Full Text PDFSubstance use disorder (SUD) is a persistent public health issue that necessitates the exploration of novel therapeutic interventions. Low-intensity focused ultrasound (LIFU) is a promising modality for precise and invasive modulation of brain activity, capable of redefining the landscape of SUD treatment. The review overviews effective LIFU neuromodulatory parameters and molecular mechanisms, focusing on the modulation of reward pathways in key brain regions in animal and human models.
View Article and Find Full Text PDFArticle Synopsis
- Opioid use during pregnancy can cause serious health issues for infants, like neonatal opioid withdrawal syndrome (NOWS), which involves various dysfunctions that require tailored treatment approaches.* -
- A study on neonatal mice revealed increased ultrasonic vocalizations (USVs) during opioid withdrawal, with significant behavioral and mRNA changes associated with kappa opioid receptors implicated in stress responses.* -
- Findings suggest that the kappa opioid receptor plays a critical role in withdrawal-related distress, particularly in female mice, highlighting variations in USV patterns and responses in males and females during this process.*
Sex Differences in the Development of an Opioid Addiction-Like Phenotype: A Focus on the Telescoping Effect.
Biol Psychiatry Glob Open Sci
November 2024
Background: Women develop addiction and drug-related health consequences after fewer years of drug use than men; this accelerated time course, or telescoping effect, has been observed clinically for multiple drugs, including opioids. Preclinical studies indicate that this is a biologically based phenomenon; however, these studies have focused exclusively on cocaine, and none have considered health effects.
Methods: In this study, we used a rat (Sprague Dawley) model to determine sex differences in the time course for the development of an opioid addiction-like phenotype, as defined by the development of physical dependence (withdrawal-induced weight loss) and an increase in motivation for fentanyl (under a progressive-ratio schedule).