Publications by authors named "W J Lane"
Clear cell renal cell carcinoma (ccRCC), despite having a low mutational burden, is considered immunogenic because it occasionally undergoes spontaneous regressions and often responds to immunotherapies. The signature lesion in ccRCC is inactivation of the VHL tumor suppressor gene and consequent upregulation of the HIF transcription factor. An earlier case report described a ccRCC patient who was cured by an allogeneic stem cell transplant and later found to have donor-derived T cells that recognized a ccRCC-specific peptide encoded by a HIF-responsive endogenous retrovirus (ERV), ERVE-4.
View Article and Find Full Text PDFObjective: Thrombocytopenia is a common complication of hematopoietic stem-cell transplantation (HSCT), though many patients will become immune refractory to platelet transfusions over time. We built and evaluated an electronic health record (EHR)-integrated, standards-based application that enables blood-bank clinicians to match platelet inventory with patients using data previously not available at the point-of-care, like human leukocyte antigen (HLA) data for donors and recipients.
Materials And Methods: The web-based application launches as an EHR-embedded application or as a standalone application.
Article Synopsis
- Habitat partitioning allows brown and white shrimp to coexist by using estuarine habitats at different times, although they do overlap, particularly towards the end of their nursery residency.
- Laboratory experiments tested how the density and presence of each shrimp species impacted their growth and mortality rates.
- The study found that species identity influenced growth and survival, with smaller shrimp having higher mortality, indicating environmental changes could affect their populations in varying ways.
Thigh-based free flaps are a common second-line options in autologous breast reconstruction when the abdominal donor site is unavailable. While the profunda artery perforator (PAP) flap and gracilis-based flaps are most commonly utilized in this scenario, certain anatomic variations may favor alternative flap selection. One such option is the medial circumflex femoral artery perforator flap (MCFLAP).
View Article and Find Full Text PDFArticle Synopsis
- * Anti-ABO antibodies naturally develop early in life, unlike other red blood cell antibodies, and are a major barrier to successful transfusions and transplants, with incomplete understanding of their formation.
- * Some research suggests that microbes with similar structures to ABO antigens might influence the creation of anti-ABO antibodies; however, their exact role and how the body defends against this mimicry via galectins need further exploration.