Publications by authors named "W J Hellstrom"
Background: Cytokines and growth factors (GF) have been implicated in the development of retinopathy of prematurity (ROP) and bronchopulmonary dysplasia (BPD). We hypothesize that even small coordinated changes in inflammatory proteins or GFs may reveal changes in underlying regulating mechanisms that do not induce obvious changes in concentration of individual proteins. We therefore applied correlation network analysis of serum factors to determine early characteristics of these conditions.
View Article and Find Full Text PDFFetal haemoglobin and oxygen requirement in preterm infants: an observational study.
Arch Dis Child Fetal Neonatal Ed
September 2024
Article Synopsis
- The study investigates how the fraction of fetal hemoglobin (HbF) relates to oxygen needs in very preterm infants, focusing on the relationship between HbF, fraction of inspired oxygen (FiO), and alveolar-arterial gradient (A-a gradient).
- Conducted in a neonatal intensive care unit in southern Sweden, the longitudinal observational study analyzed data from 440 preterm infants born before gestational week 30 between 2009 and 2015.
- Results indicate that lower HbF levels are linked to higher FiO and A-a gradients, suggesting that increased oxygen exposure may contribute to bronchopulmonary dysplasia (BPD) in these infants.
Article Synopsis
- This study explores how neurofilament light chain (NfL), a marker for brain injury, relates to neurovascular issues in extremely preterm infants, specifically those born before 28 weeks gestational age.
- Researchers found that higher NfL levels in the first month after birth are associated with severe intraventricular hemorrhage (IVH) and retinopathy of prematurity (ROP), especially in infants born before 25 weeks gestational age.
- The results suggest that NfL could be a potential predictor of neonatal morbidities linked to a more porous blood-brain barrier, indicating the need for further research in this area.