Publications by authors named "W J Hawthorne"
Total pancreatectomy and islet autotransplantation (TPIAT) is an effective treatment for chronic and recurrent acute pancreatitis, and it provides a significant potential additional benefit of insulin independence. Spontaneous hypoglycemia in the absence of insulin therapy following TPIAT is a recognized complication, which has been attributed to lack of protective glucagon responses to hypoglycemia, following intrahepatic islet autotransplantation. We describe the use of liraglutide to treat spontaneous hypoglycemia following TPIAT.
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- The study investigated the use of normothermic machine perfusion (NMP) for improving outcomes in suboptimal deceased donor kidneys, specifically those from donors after circulatory death (DCD).
- A total of 18 DCD kidneys were subjected to NMP for 1 to 3 hours before transplantation, which showed high feasibility, with most kidneys experiencing at least 1 hour of perfusion.
- Results indicated a significantly lower rate of delayed graft function in kidneys that underwent NMP compared to control kidneys, while overall graft survival and function were similar over time, suggesting NMP is a safe and effective option for enhancing kidney transplant outcomes.
Article Synopsis
- * It identifies four key challenges to promoting innovation in SoHO treatments and suggests concrete solutions, emphasizing the need for collaboration, sustainability, and transparency among stakeholders.
- * The document calls for improved regulatory frameworks that ensure global quality and safety standards for SoHO while encouraging a regulatory environment that respects altruistic donation and enhances accessibility for patients.
Background: To overcome organ shortages, donation after circulatory death (DCD) kidneys are being increasingly used for transplantation. Prior research suggests that DCD kidneys have inferior outcomes compared with kidneys donated after brain death. Normothermic machine perfusion (NMP) and normothermic regional perfusion (NRP) may enhance the preservation of DCD kidneys and improve transplant outcomes.
View Article and Find Full Text PDFCD4+Foxp3+ regulatory T cells (Tregs) play an essential role in suppressing transplant rejection, but their role within the graft and heterogeneity in tolerance are poorly understood. Here, we compared phenotypic and transcriptomic characteristics of Treg populations within lymphoid organs and grafts in an islet xenotransplant model of tolerance. We showed Tregs were essential for tolerance induction and maintenance.
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