A satellite cell-dependent epigenetic fingerprint in skeletal muscle identity genes after lifelong physical activity.

Satellite cells comprise a small proportion of mononuclear cells in adult skeletal muscle. Despite their relative rarity, satellite cells have critical functions in muscle adaptation, particularly during prolonged exercise training. The mechanisms by which satellite cells mediate skeletal muscle responsiveness to physical activity throughout the lifespan are still being defined, but epigenetic regulation may play a role.

OCTA-based AMD Stage Grading Enhancement via Class-Conditioned Style Transfer.

Optical Coherence Tomography Angiography (OCTA) is a promising diagnostic tool for age-related macular degeneration (AMD), providing non-invasive visualization of sub-retinal vascular networks. This research explores the effectiveness of deep neural network (DNN) classifiers trained exclusively on OCTA images for AMD diagnosis. To address the challenge of limited data, we combine OCTA data from two instruments-Heidelberg and Optovue-and leverage style transfer technique, CycleGAN, to convert samples between these domains.

Dry eye disease treatment improves subjective quality-of-life responses in patients with AMD, independent of disease stage.

Purpose: To determine the impact of severity of age-related macular degeneration (AMD) on subjective treatment response in patients treated for dry eye disease.

Methods: A total of 203 eyes diagnosed with evaporative dry eye disease (DED) due to meibomian gland dysfunction were treated using the LipiFlow or MiBoFlo systems. From this cohort, 40 eyes with stable dry AMD (early, intermediate, or late stages) were included.