Publications by authors named "W J De Villiers"
Article Synopsis
- * Researchers performed a multi-omic analysis (using various advanced techniques) on samples from two AML patients to explore genetic and epigenetic alterations from diagnosis to relapse.
- * Key findings revealed that relapse involves significant changes in the 3D structure of chromatin and a decrease in accessible chromatin regions, which affect gene regulation, emphasizing the need for comprehensive approaches in studying relapse mechanisms for potential new therapies.
Previous research has shown that the Serum Amyloid A (SAA) protein family is intricately involved in inflammatory signaling and various disease pathologies. We have previously demonstrated that SAA is associated with increased colitis disease severity and the promotion of tumorigenesis. However, the specific role of SAA proteins in breast cancer pathology remains unclear.
View Article and Find Full Text PDFLiposomal daunorubicin and cytarabine (CPX-351) improved overall survival (OS) compared with 7+3 chemotherapy in older patients with secondary acute myeloid leukemia (AML); to date, there have been no randomized studies in younger patients. The high-risk cohort of the UK NCRI AML19 trial (ISRCTN78449203) compared CPX-351 with FLAG-Ida in younger adults with newly diagnosed adverse cytogenetic AML or high-risk myelodysplastic syndromes (MDS). A total of 189 patients were randomized (median age, 56 years).
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- - The PML::RARA fusion protein is crucial in causing Acute Promyelocytic Leukemia (APL) by disrupting retinoic acid signaling, which leads to abnormal gene expression and growth of myeloid precursor cells.
- - Research using multi-omics data shows that PML::RARA does not uniformly repress genes; instead, it can also activate some genes or leave them unchanged.
- - A new computational method called Regulatory Element Behavior Extraction Learning has been developed to analyze how PML::RARA interacts with transcription factors at its binding sites, uncovering specific patterns that influence gene regulation.
In this paper the effects of the addition of a paraffin phase change material on the strength and printability of 3D printed concrete are studied. Phase change materials are latent heat storing materials, which garner and release large amounts of energy as they change phase. The addition of phase change materials to concrete produces a composite material with maximised latent and sensible heat storage capacity.
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