Estimating surgical blood loss: A review of current strategies in various clinical settings.

The estimation of surgical blood loss is routinely performed during and after surgical procedures and has morbidity and mortality implications related to the risk of under- and over-resuscitation. The strategies for estimating surgical blood loss include visual estimation, the gravimetric method, the colorimetric method, formula-based methods, and other techniques (e.g.

Compartmentalised single-chain nanoparticles and their function.

Single-chain nanoparticles (SCNPs) are generated by intramolecular collapse and crosslinking of single polymer chains, thus conceptually resembling the structures of folded proteins. Their chemical flexibility and ability to form compartmentalised nanostructures sized ∼1 nm make them perfect candidates for numerous applications, such as in catalysis and drug delivery. In this review we discuss principles for the design, synthesis and analysis of SCNPs, with a focus on their compartmentalised structures, highlighting our own previous work.

Lipid-polymer hybrid-vesicles interrupt nucleation of amyloid fibrillation.

Solubility and aggregation of proteins are crucial factors for their functional and further biological roles. Aggregation of proteins , such as the amyloid beta (Aβ) peptide into fibrils, is significantly modulated by membrane lipids, abundantly present in cells. We developed a model membrane system, composed of lipid hybrid-vesicles bearing embedded hydrophilic polymers to study the aggregation of the Aβ peptide.