Redox properties of [Cp*Rh] complexes supported by mono-substituted 2,2'-bipyridyl ligands.

The redox properties of half-sandwich rhodium complexes supported by 2,2'-bipyridyl (bpy) ligands can be readily tuned by selection of an appropriately substituted derivative of bpy, but the influences of single substituents on the properties of such complexes are not well documented, as disubstituted bpy variants are much more common. Here, the synthesis, characterization, and redox properties of two new [Cp*Rh] complexes (where Cp* is η-1,2,3,4,5-pentamethylcyclopentadienyl) supported by the uncommon mono-substituted ligands 4-chloro-2,2'-bipyridyl (mcbpy) and 4-nitro-2,2'-bipyridyl (mnbpy) are reported. Single-crystal X-ray diffraction studies and related spectroscopic experiments confirm installation of the single substituents (-Cl and -NO, respectively) on the bipyridyl ligands; the precursor monosubstituted ligands were prepared a divergent route from unsubstituted bpy.

The Role of the Tyrosine-Based Sorting Signals of the ORF3a Protein of SARS-CoV-2 on Intracellular Trafficking, Autophagy, and Apoptosis.

The open reading frame 3a (ORF3a) is an accessory transmembrane protein that is important to the pathogenicity of SARS-CoV-2. The cytoplasmic domain of ORF3a has three canonical tyrosine-based sorting signals (YxxΦ; where x is any amino acid and Φ is a hydrophobic amino acid with a bulky -R group). They have been implicated in the trafficking of membrane proteins to the cell plasma membrane and to intracellular organelles.

Homoleptic complexes of isocyano- and diisocyanobiazulenes with a 12-electron, ligand-based redox capacity.

Oligo- and polyazulenes are attractive π-conjugated building blocks in designing advanced functional materials. Herein, we demonstrate that anchoring one or both isocyanide termini of the redox non-innocent 2,2'-diisocyano-6,6'-biazulenic π-linker (1) to the redox-active [Cr(CO)] moiety provided a convenient intramolecular redox reference for unambiguously establishing that the 6,6'-biazulenic scaffold undergoes a reversible one-step 2 reduction governed by reduction potential compression/inversion. Treatment of bis(η-naphthalene)chromium(0) with six equiv.

SARS-CoV-2 Harnesses Host Translational Shutoff and Autophagy To Optimize Virus Yields: the Role of the Envelope (E) Protein.

The SARS-CoV-2 virion is composed of four structural proteins: spike (S), nucleocapsid (N), membrane (M), and envelope (E). E spans the membrane a single time and is the smallest, yet most enigmatic of the structural proteins. E is conserved among coronaviruses and has an essential role in virus-mediated pathogenesis.