Publications by authors named "W Hashimoto"

Article Synopsis
  • This study investigates how marine microorganisms break down brown algae, focusing on the interaction between prokaryotic and eukaryotic microbes involved in the metabolism of brown algae carbohydrates.
  • Amplicon-based microbiome analysis showed that specific genera were predominant in seawater and seaweed samples enriched with alginate and mannitol, key carbohydrates found in brown algae.
  • The research revealed that coculturing certain yeast with algae-decomposing microbes not only enhances yeast growth but also leads to valuable lipid production, highlighting the potential for mutualistic interactions to create useful substances in marine environments.
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Clostridium perfringens, an opportunistic pathogen, produces mu-toxin hyaluronidases including endo-β-N-acetylglucosaminidases (Nags) as a virulence invasion factor. To clarify an intrinsic factor for degradation of host extracellular hyaluronan, we focused on hyaluronate lyase (HysA), distinct from endo-β-N-acetylglucosaminidases. C.

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Article Synopsis
  • Trastuzumab-deruxtecan (T-DXd) is an approved treatment for advanced HER2-positive gastric cancer in Japan, backed by the DESTINY-Gastric01 trial results.* -
  • The retrospective study analyzed 312 patients, revealing a median overall survival of 8.9 months, with 42.9% showing a positive response to treatment, while monitoring adverse effects that were primarily manageable.* -
  • The findings suggest that T-DXd is effective and safe as a third-line or later option for patients, indicating its potential role in real-world clinical practice for this cancer type.*
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Brown algae are one of the most abundant biomasses on Earth. To recycle them as blue carbon sources, an effective decomposition system is necessary. This study focused on microorganisms present in seawater that decompose brown algae which contain laminarin and alginate.

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