Biomarkers.

Background: The initiation of cognitive impairment is triggered by a myriad of pathological events occurring decades before clinical symptoms manifest. Perturbed glucose and fatty acid metabolism notably contribute to the development of cognitive impairment, progressing further into clinical dementia. These metabolic alterations are evident in plasma through changes in specific metabolites.

Public Health.

Background: Social connections are linked to brain health. Studies to date have ignored negative social connections and the association between social connections and white matter health. We explored the relationship between positive and negative social connections and brain imaging including white matter health.

Modulating tumor-associated macrophages through CSF1R inhibition: a potential therapeutic strategy for HNSCC.

Purpose: Tumor-associated macrophages (TAMs) are pivotal immune cells within the tumor microenvironment (TME), exhibiting dual roles across various cancer types. Depending on the context, TAMs can either suppress tumor progression and weaken drug sensitivity or facilitate tumor growth and drive therapeutic resistance. This study explores whether targeting TAMs can suppress the progression of head and neck squamous cell carcinoma (HNSCC) and improve the efficacy of chemotherapy.

Prediction of the likelihood of conception to first or second insemination in Chinese Holstein cows using milk Fourier transformed infrared spectroscopy.

Accurate identification of cows' likelihood of conception during the period from recent calving to the first artificial insemination (AI) will provide assistance in managing the fertility of dairy cows and contribute to the economic prosperity and sustainability of the farm. The purpose of this study was to use FTIR spectroscopy collected from recent calving to the first artificial insemination (AI) to predict the cow's likelihood of conception to first AI, first or second AI. This study specifically focused on the role of FTIR spectral and farm data collected at different time windows in improving the accuracy of model for predicting the cow's likelihood of conception to first AI, first or second AI.

Association of the geriatric nutritional risk index with poor outcomes in patients with coronary revascularization: a cohort study.

Background: Poor nutritional status may affect outcomes after coronary revascularization, but the association between nutritional status and outcomes in patients undergoing coronary revascularization has not been fully evaluated. This study was based on the MIMIC-IV database to analyze the impact of baseline nutritional status on poor outcomes in patients with coronary revascularization.

Methods: Patients with coronary revascularization were screened from the MIMIC-IV database.