Association between fasting blood glucose and psychotic symptoms in Chinese patients with first-episode drug-naïve major depressive disorder.

Introduction: Psychotic depression (PD) is a highly debilitating disorder characterized by hallucinations and/or delusions accompanied by depression. A variety of neurotransmitters, hormones and corresponding receptors in the endocrine system are involved in the onset and progression of depression, and fasting blood glucose (FBG) can be an important indicator for monitoring the stability of the endocrine system. The aim of this study was to investigate the relationship between FBG and PD in a Chinese population with first-episode drug-naïve (FEDN) major depressive disorder (MDD).

Failure and development height of overlying rock of a water flowing fracture in goaf under a karst aquifer.

The factors leading to mine water inrush accidents are mainly sources of water, water channels, and intensity of water inrush. Mine water rush depends mostly on whether damage leads to the overlying strata of the working face penetrating the overlying aquifer. There is therefore a need to characterize how the overlying strata of the coal seam roof fails and the development height of the water-conducting fracture zone during a roof water inrush incident.

Applying hollow octahedron PtNPs/Pd-CuO nanozyme and highly conductive AuPtNPs/Ni-Co NCs to colorimetric -electrochemical dual-mode aptasensor for AFB1 detection.

Background: Aflatoxin B1 (AFB1) is a secondary metabolite produced by Aspergillus flavus and Aspergillus parasiticus. This toxin is highly carcinogenic and toxic, posing a serious threat to human and animal health. AFB1 primarily enters the human body through contaminated food, particularly peanuts, corn, nuts, and wheat.

'Splice-at-will' Cas12a crRNA engineering enabled direct quantification of ultrashort RNAs.

We present a robust 'splice-at-will' CRISPR RNA (crRNA) engineering mechanism that overcomes the limitations of clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system in directly detecting ultrashort RNAs. In this strategy, an intact Cas12a crRNA can be split from almost any site of the spacer region to obtain a truncated crRNA (tcrRNA) that cannot activate Cas12a even after binding an auxiliary DNA activator. While splicing tcrRNAs with a moiety of ultrashort RNA, the formed combination can work together to activate Cas12a efficiently, enabling 'splice-at-will' crRNA engineering.

Dual-mode ratiometric fluorescent and colorimetric sensor for rapid visual detection of Hg using poly(T)-tailed ssDNA-silver nanoclusters.

Rapid, sensitive, and accurate detection of heavy metal ions is significant for human health and ecological security. Herein, a novel single-stranded DNA with poly(thymidine) tail is tactfully designed as template to synthesize dual-emission silver nanoclusters (ssDNA-AgNCs). The obtained AgNCs simultaneously emit red and green fluorescence, and the red emission can be selectively quenched by Hg, meanwhile the green emission of AgNCs increases synchronously.