Towards Real-time Metabolic Profiling of Cancer with Hyperpolarized Succinate.

Purpose: The energy-yielding mitochondrial Krebs cycle has been shown in many cancers and other diseases to be inhibited or mutated. In most cells, the Krebs cycle with oxidative phosphorylation generates approximately 90% of the adenosine triphosphate in the cell. We designed and hyperpolarized carbon-13 labeled succinate (SUC) and its derivative diethyl succinate (DES) to interrogate the Krebs cycle in real-time in cancer animal models.

Tibiofemoral and patellofemoral mechanics are altered at small knee flexion angles in people with patellofemoral pain.

Objectives: To test the hypothesis that, at 0° and 20° of knee flexion, patellofemoral contact area would be lower, while tibiofemoral rotation and patellofemoral malalignment would be higher in participants with patellofemoral pain (PFP) compared to pain-free participants. We hypothesized that no differences would be detected at 40° due to increasing patellar stability.

Design: Cross-sectional, descriptive study.

Fast volumetric spatial-spectral MR imaging of hyperpolarized 13C-labeled compounds using multiple echo 3D bSSFP.

Purpose: The goal of this work was to develop a fast 3D chemical shift imaging technique for the noninvasive measurement of hyperpolarized (13)C-labeled substrates and metabolic products at low concentration.

Materials And Methods: Multiple echo 3D balanced steady state magnetic resonance imaging (ME-3DbSSFP) was performed in vitro on a syringe containing hyperpolarized [1,3,3-2H3; 1-(13)C]2-hydroxyethylpropionate (HEP) adjacent to a (13)C-enriched acetate phantom, and in vivo on a rat before and after intravenous injection of hyperpolarized HEP at 1.5 T.

Magnetic resonance measurement of diffusion in the abdomen.

Diffusion-weighted (DW) magnetic resonance imaging is an emerging noninvasive technique increasing its spectrum of use in the abdomen. Diffusion-weighted imaging has been used as add-on to routine abdominal protocol because it may potentially substitute contrast-enhanced imaging in cases under risk of nephrogenic systemic fibrosis. The apparent diffusion coefficient (ADC) images calculated from DW images enable qualitative and quantitative evaluations of tissue water mobility and functional environment because of changes in intracellular, extracellular, and intravascular tissue compartments.

Review of magnetic resonance spectroscopy in the liver and the pancreas.

Proton magnetic resonance spectroscopy is a powerful tool for in vivo biochemical characterization of normal and abnormal tissues. The initial application in the abdomen was the measurement of fat concentration in the liver using chemical shift imaging. The success of chemical shift imaging in providing a semiquantitative measure of liver fat concentration led to the application of the more quantitative single-voxel volume-selective spectroscopy of the liver.