Task Activation Results in Regional C-Lactate Signal Increase in the Human Brain.

Hyperpolarized- C magnetic resonance imaging (HP- C MRI) was used to image changes in C-lactate signal during a visual stimulus condition in comparison to an eyes-closed control condition. Whole-brain C-pyruvate, C-lactate and C-bicarbonate production was imaged in healthy volunteers (N=6, ages 24-33) for the two conditions using two separate hyperpolarized C-pyruvate injections. BOLD-fMRI scans were used to delineate regions of functional activation.

Evidence of C-lactate oxidation in the human brain from hyperpolarized C-MRI.

Purpose: To test the hypothesis that lactate oxidation contributes to the C-bicarbonate signal observed in the awake human brain using hyperpolarized C MRI.

Methods: Healthy human volunteers (N = 6) were scanned twice using hyperpolarized C-MRI, with increased radiofrequency saturation of C-lactate on one set of scans. C-lactate, C-bicarbonate, and C-pyruvate signals for 132 brain regions across each set of scans were compared using a clustered Wilcoxon signed-rank test.

Age-associated change in pyruvate metabolism investigated with hyperpolarized C-MRI of the human brain.

In this study, hyperpolarized C MRI (HP- C MRI) was used to investigate changes in the uptake and metabolism of pyruvate with age. Hyperpolarized C-pyruvate was administered to healthy aging individuals (N = 35, ages 21-77) and whole-brain spatial distributions of C-lactate and C-bicarbonate production were measured. Linear mixed-effects regressions were performed to compute the regional percentage change per decade, showing a significant reduction in both normalized C-lactate and normalized C-bicarbonate production with age: per decade for C-lactate and per decade for C-bicarbonate.

Predicting response to radiotherapy of intracranial metastases with hyperpolarized [Formula: see text]C MRI.

Background: Stereotactic radiosurgery (SRS) is used to manage intracranial metastases in a significant fraction of patients. Local progression after SRS can often only be detected with increased volume of enhancement on serial MRI scans which may lag true progression by weeks or months.

Methods: Patients with intracranial metastases (N = 11) were scanned using hyperpolarized [Formula: see text]C MRI prior to treatment with stereotactic radiosurgery (SRS).

Stability of Generic Formulations of Bortezomib 1.0 and 2.5 mg/mL in Vials and Syringes Stored at 4°C and Room Temperature (23°C or 25°C).

Background: The availability of generic versions of bortezomib raises questions about the reliability of extrapolating stability data from one brand to another.

Objective: To evaluate the stability of bortezomib formulations available from Janssen, Teva Canada, Actavis Pharma, Dr. Reddy's Laboratories, Apotex, and MDA, reconstituted with 0.