Clinical Manifestations.

Background: Behavioral and psychological symptoms of dementia (BPSD) are highly prevalent in people living with dementia. Atypical antipsychotics (AAPs) are commonly used to treat BPSD, but their comparative efficacy and acceptability are unknown.

Methods: This study was conducted following the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA).

The Effect of Clostridium butyricum-Derived Lipoteichoic Acid on Lipopolysaccharide-Stimulated Porcine Intestinal Epithelial Cells.

Background: Clostridium butyricum is a probiotic widely used in animal husbandry, and there is evidence to suggest that it can alleviate intestinal inflammation in pigs and may be related to its lipoteichoic acid (LTA), but the mechanism is still unclear.

Objective: This study aimed to determine the regulatory effect and potential mechanism of C. butyricum LTA on LPS-stimulated inflammation in intestinal porcine epithelial line-J2 (IPEC-J2).

Rapid High-Throughput Discovery of Molecules With Antimicrobial Activity From Natural Products Enabled by a Nanoliter Matrix SlipChip.

Improper use of antibiotics has led to the development of antimicrobial resistance, or "superbugs," outpacing the discovery of new antibiotics. The lack of rapid, high-throughput screening methods is a major bottleneck in discovery novel antibiotics. Traditional methods consume significant amounts of samples, making it challenging to discover new antibiotics from limited natural product extracts.

Using ERPs to unveil the authenticity evaluation and neural response to online rumors.

The rapid propagation of information in the digital epoch has brought a surge of rumors, creating a significant societal challenge. While prior research has primarily focused on the psychological aspects of rumors-such as the beliefs, behaviors, and persistence they evoke-there has been limited exploration of how rumors are processed in the brain. In this study, we experimented to examine both behavioral responses and EEG data during rumor detection.

Selective Electroreduction of CO2 to CO over Ultrawide Potential Window via Implanting Active Site with Long-Range P Regulation on Periodic Pores.

Electroreduction of CO2 to CO represents a highly promising way for artificial carbon cycling, but obtaining high selectivity over a wide potential window remains a challenge due to the sluggish CO generation and diffusion kinetics. Here we report an integration of long-range P modified asymmetrical bismuth atomic site on an ordered macroporous carbon skeleton with mesoporous "wall" (MW-BiN3-POMC) for efficient electroreduction of CO2. In-depth in-situ investigations with theoretical computations reveal that the incorporation of long-range P atom is able to strengthen the orbital interaction between the C 2p of CO2 and Bi 6p, thereby establishing an electronic transport bridge for the activation of CO2 molecule.