Publications by authors named "W H Lippitt"
. Sarcoidosis is a granulomatous disease affecting the lungs in over 90% of patients. Qualitative assessment of chest CT by radiologists is standard clinical practice and reliable quantification of disease from CT would support ongoing efforts to identify sarcoidosis phenotypes.
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- The study investigates the link between plasma glial fibrillary acidic protein (GFAP) and amyloid levels in relation to cognitive outcomes, focusing on the fornix structure in individuals with Alzheimer's disease (AD).
- Researchers assessed plasma GFAP and amyloid-β42 levels in a cohort of 99 older adults and used advanced imaging techniques to evaluate the fornix, a brain structure important for memory.
- Results showed that higher plasma GFAP levels correlated with microstructural changes in the fornix, which in turn mediated the relationship between GFAP and verbal memory performance, particularly in individuals with low amyloid levels.
It is now common to have a modest to large number of features on individuals with complex diseases. Unsupervised analyses, such as clustering with and without preprocessing by Principle Component Analysis (PCA), is widely used in practice to uncover subgroups in a sample. However, in many modern studies features are often highly correlated and noisy (e.
View Article and Find Full Text PDFBackground: Sarcoidosis staging primarily has relied on the Scadding chest radiographic system, although chest CT imaging is finding increased clinical use.
Research Question: Whether standardized chest CT scan assessment provides additional understanding of lung function beyond Scadding stage and demographics is unknown and the focus of this study.
Study Design And Methods: We used National Heart, Lung, and Blood Institute study Genomics Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) cases of sarcoidosis (n = 351) with Scadding stage and chest CT scans obtained in a standardized manner.
Objective: Sarcoidosis is a granulomatous disease affecting the lungs in over 90% of patients. Qualitative assessment of chest CT by radiologists is standard clinical practice and reliable quantification of disease from CT would support ongoing efforts to identify sarcoidosis phenotypes. Standard imaging feature engineering techniques such as radiomics suffer from extreme sensitivity to image acquisition and processing, potentially impeding generalizability of research to clinical populations.
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