Neural network classification of beams carrying orbital angular momentum after propagating through controlled experimentally generated optical turbulence.

We generate an alphabet of spatially multiplexed Laguerre-Gaussian beams carrying orbital angular momentum, which are demultiplexed at reception by a convolutional neural network (CNN). In this investigation, a methodology for optimizing alphabet design for best classification rates is proposed, and three 256-symbol alphabets are designed for performance evaluation in optical turbulence. The beams were propagated in three environments: through underwater optical turbulence generated by Rayleigh-Bénard (RB) convection ( 2≅10 ), through a simulated propagation path derived from the Nikishov spectrum ( 2≅10 ), and through optical turbulence from a thermal point source located in a water tank ( 2≅10 ).

The continued need for animals to advance brain research.

Policymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience research, until viable and translational alternatives become available and the value of these alternatives has been proven, the use of animals should not be compromised.

International primate neuroscience research regulation, public engagement and transparency opportunities.

Scientific excellence is a necessity for progress in biomedical research. As research becomes ever more international, establishing international collaborations will be key to advancing our scientific knowledge. Understanding the similarities in standards applied by different nations to animal research, and where the differences might lie, is crucial.

Effects of Stereochemistry and Hydrogen Bonding on Glycopolymer-Amyloid-β Interactions.

Saccharide stereochemistry plays an important role in carbohydrate functions such as biological recognition processes and protein binding. Synthetic glycopolymers with pendant saccharides of controlled stereochemistry provide an attractive approach for the design of polysaccharide-inspired biomaterials. Acrylamide-based polymers containing either β,d-glucose or β,d-galactose pendant groups, designed to mimic GM1 ganglioside saccharides, and their small-molecule analogues were used to evaluate the effect of stereochemistry on glycopolymer solution aggregation processes alone and in the presence of Aβ42 peptide using dynamic light scattering, gel permeation chromatography-multiangle laser light scattering, and fluorescence assays.