Drugs repurposing in the experimental models of Alzheimer's disease.

The currently approved drugs for Alzheimer's disease (AD) are only for symptomatic treatment in the early stages of the disease but they could not halt the neurodegeneration, additionally, the safety profile of the recently developed immunotherapy is a big issue. This review aims to explain the importance of the drugs repurposing technique and strategy to develop therapy for AD. We illustrated the biological alterations in the pathophysiology of AD including the amyloid pathology, the Tau pathology, oxidative stress, mitochondrial dysfunction, neuroinflammation, glutamate-mediated excitotoxicity, insulin signaling impairment, wingless-related integration site/β-catenin signaling, and autophagy.

Cerebral Venous Sinus Thrombosis Linked to Dietary Supplement Use in a Bodybuilder: A Case Report.

Many dietary supplements commonly used by bodybuilders and athletes carry thrombogenic risks, potentially leading to life-threatening conditions like arterial and venous thrombosis by either elevating testosterone levels or directly interfering with homeostasis. Increased awareness and further research are crucial for consumer safety and supplement regulation.

Comparative study between intrathecal fentanyl and dorsal penile nerve block for controlling postoperative pain after inflatable penile prosthesis implantation.

Objectives: To compare the efficacy of intrathecal fentanyl and dorsal penile nerve block for postoperative pain management in patients undergoing inflatable penile prosthesis (IPP).

Patients And Methods: A prospective single-center study included 80 patients amenable to IPP. Patients were divided equally into two groups.

Curcumin as a novel therapeutic candidate for cancer: can this natural compound revolutionize cancer treatment?

Cancer remains one of the leading causes of death worldwide. Despite advances in medical treatments, current therapeutic strategies, including radiotherapy, chemotherapy, targeted therapy, and surgical resection, have not significantly reduced the global incidence and mortality rates of cancer. Oncologists face considerable challenges in devising effective treatment plans due to the adverse side effects associated with standard therapies.