Antibiotic-based micelles with bone-targeting and pH-responsive properties for infectious osteomyelitis treatment.

We developed antibiotic-based micelles with bone-targeting and charge-switchable properties (P-CASMs) for treating infectious osteomyelitis. The amphiphilic molecules are formed by combining ciprofloxacin (CIP) with ligand 1 through a mild salifying reaction, and spontaneously self-assemble into antibiotic-based micelles (ASMs) in aqueous solution. Acrylate groups on ligand 1 enable cross-linking of ASMs with pentaerythritol tetra(mercaptopropionate) via a click reaction, forming pH-sensitive cross-linked micelles (CASMs).

Remaining Useful Life Prediction of Rolling Bearings Based on CBAM-CNN-LSTM.

Predicting the Remaining Useful Life (RUL) is vital for ensuring the reliability and safety of equipment and components. This study introduces a novel method for predicting RUL that utilizes the Convolutional Block Attention Module (CBAM) to address the problem that Convolutional Neural Networks (CNNs) do not effectively leverage data channel features and spatial features in residual life prediction. Firstly, Fast Fourier Transform (FFT) is applied to convert the data into the frequency domain.

Enhanced Control Efficacy of Different Insecticides Mixed with Mineral Oil Against Asian Citrus Psyllid, Kuwayama, Under Varying Climates.

Asian citrus psyllid (ACP), (Hemiptera: Liviidae), is one of the most devastating pests in citrus orchards due to its role in transmitting Huanglongbing (HLB). Currently, chemical control remains the most effective strategy for ACP management. Mineral oils are commonly used as insecticides or adjuvants in integrated pest management (IPM) practices.

Distance Measurement and Error Compensation of High-Speed Coaxial Rotor Blades Based on Coded Ultrasonic Ranging.

Coaxial rotor helicopters have many advantages and have a wide range of civilian and military applications; however, there is a risk of blade collision between the upper and lower rotor blades, and the challenge still exists in balancing rotor parameters and flight control. In this paper, a blade tip distance measurement method based on coded ultrasonic ranging and phase triggering is proposed to tackle this measurement environment and expand the application of ultrasonic ranging in high-speed dynamic measurement. The time of flight () of coded ultrasonic ranging is calculated by the amplitude threshold improvement method and cross-correlation method, and the sound velocity is compensated by a proposed multi-factor compensation method.

[Evaluation of micro crestal flap-alveolar ridge preservation following extraction of mandibular molars with severe periodontitis].

Objective: To evaluate the clinical and radiographic efficacy of micro crestal flap-alveolar ridge preservation following extraction of mandibular molars with severe periodontitis compared with natural healing, and to preliminarily propose the surgical indication.

Methods: A retrospective analysis was conducted on clinical data from patients with mandibular molars with severe periodontitis either receiving micro crestal flap-alveolar ridge preservation (MCF-ARP group) or undergoing natural healing in department of periodontology, Peking University School and Hospital of Stomatology from September 2013 to June 2021. Cone-beam computed tomography scannings performed before/immediately after extraction (as baseline) and repeated before implantation (after the extraction socket healing) were used to measure the ridge width, height and volumetric changes of the sockets, and the proportion of guided bone regeneration (GBR) during implant therapy were compared between the two groups.