Effect of Microfracture on Meniscal Tear Healing in a Goat (Capra hircus) Model.

Meniscal injuries are an extremely common cause of knee pain. Meniscal repairs performed with concomitant anterior cruciate ligament reconstruction appear to heal at a higher rate than meniscal repairs performed in isolation. This may be due in part to the release of marrow elements into the knee and the time of meniscal repair.

Tibial tubercle fractures in children with intra-articular involvement: surgical tips for technical ease.

Background: Tibial tubercle fractures often occur in athletic adolescents close to skeletal maturity. These fractures can present with marked displacement of the apophysis, intra-articular extension, and associated soft tissue injuries, such as tibial meniscal ligament tears. Here, we present our surgical technique which focuses on recreating the meniscal-articular relationship (using suture anchors) in severely displaced fractures.

CO(2) in large-scale and high-density CHO cell perfusion culture.

Productivity in a CHO perfusion culture reactor was maximized when pCO(2) was maintained in the range of 30-76 mm Hg. Higher levels of pCO(2) (> 150 mm Hg) resulted in CHO cell growth inhibition and dramatic reduction in productivity. We measured the oxygen utilization and CO(2) production rates for CHO cells in perfusion culture at 5.

Comparative in vitro antifungal activity of amphotericin B and amphotericin B methyl ester.

The in vitro antifungal activity of amphotericin B methyl ester (AME), a water-soluble derivative of amphotericin B, was compared to that of the parent compound against a variety of pathogenic and potentially pathogenic fungi. AME has a significant antifungal activity, but the activity of AME was slightly lower than that of amphotericin B. Among the yeast-like organisms, only the yeast cells of Sporothrix schenckii were more resistant than others to both antibiotics, with a minimal fungicidal concentration of 5 to 10 mug/ml.