Borne of necessity: Pharmacy-based harm reduction and express sexually transmitted infection services.

Background: HIV, hepatitis C virus (HCV), Sexually Transmitted Infections (STIs), and substance use disorder are interrelated epidemics. Augmented services to respond to this "syndemic" are hampered by shortages of health care workers, especially in rural areas. In an Indian Health Service hospital in rural Minnesota, the pharmacy sought to integrate harm reduction and express STI services into its scope of practice.

Spatiotemporal tracking of gold nanorods after intranasal administration for brain targeting.

Intranasal administration is becoming increasingly more attractive as a fast delivery route to the brain for therapeutics circumventing the blood-brain barrier (BBB). Gold nanorods (AuNRs) demonstrate unique optical and biological properties compared to other gold nanostructures due to their high aspect ratio. In this study, we investigated for the first time the brain region-specific distribution of AuNRs and their potential as a drug delivery platform for central nervous system (CNS) therapy following intranasal administration to mice using a battery of analytical and imaging techniques.

The long-distance flight behavior of supports an agent-based model for wind-assisted dispersal in insects.

Despite the ecological importance of long-distance dispersal in insects, its mechanistic basis is poorly understood in genetic model species, in which advanced molecular tools are readily available. One critical question is how insects interact with the wind to detect attractive odor plumes and increase their travel distance as they disperse. To gain insight into dispersal, we conducted release-and-recapture experiments in the Mojave Desert using the fruit fly, We deployed chemically baited traps in a 1 km radius ring around the release site, equipped with cameras that captured the arrival times of flies as they landed.

Rational design of bimetallic photocatalysts based on plasmonically-derived hot carriers.

Hot carriers generated by plasmonic excitations have recently opened up new avenues in photocatalysis. The transfer of these energetic carriers to adjacent molecules can promote chemical transformations that are important for hydrogen generation by water splitting, CO reduction and degradation of organic pollutants. Here, we have developed and optimised a plasmonic hot-carrier catalytic system based on silica nanoparticles decorated with plasmonic gold nanoparticles as a source of hot carriers, equipped with platinum nanoclusters as co-catalyst for the enhancement of hot-carrier extraction.