The wrapped Rama distribution.

A new one-parameter distribution is proposed for circular data based on wrapping. Most distributions constructed via wrapping do not yield elementary expressions for their mathematical properties. Yet the new distribution yields elementary expressions for all of its mathematical properties.

Severe Gingival Enlargement Associated With Methamphetamine Abuse: A Case Report.

Gingival enlargement (GE) is characterized by the overgrowth of gingival tissues, often exacerbated by dental biofilm and certain medications or substances. This report presents a case of severe GE in a 61-year-old male with generalized stage 4, grade C periodontitis linked to methamphetamine use, which the patient disclosed occurred during a period of homelessness. The treatment involved antibiotic therapy, extractions, gingivectomy, gingivoplasty, and osteoplasty to facilitate future oral rehabilitation.

A flavonoid-rich diet is associated with lower risk and improved imaging biomarkers of nonalcoholic fatty liver disease: a prospective cohort study.

Background: Mechanistic studies and short-term randomized trials suggest higher intakes of dietary flavonoids may protect against nonalcoholic fatty liver disease (NAFLD).

Objectives: We aimed to perform the first population-based study with long-term follow-up on flavonoid consumption, incident NAFLD, and validated NAFLD biomarkers.

Methods: In a prospective study, we assessed the associations between flavonoid intake based on ≥2 24-h dietary assessments and NAFLD risk among 121,064 adults aged 40-69 y by multivariable Cox regression analyses.

Association between substituting macronutrients and all-cause mortality: a network meta-analysis of prospective observational studies.

Background: Suboptimal diet quality is a key risk factor for premature death. Assuming relatively stable energy intake among individuals, changes in nutrient intakes occur by exchanging different nutrients. Therefore we aimed to examine the association of isocaloric substitution of dietary (macro)nutrients with all-cause mortality using network meta-analysis (NMA).

VISTA Emerges as a Promising Target against Immune Evasion Mechanisms in Medulloblastoma.

Background: Relapsed medulloblastoma (MB) poses a significant therapeutic challenge due to its highly immunosuppressive tumor microenvironment. Immune checkpoint inhibitors (ICIs) have struggled to mitigate this challenge, largely due to low T-cell infiltration and minimal PD-L1 expression. Identifying the mechanisms driving low T-cell infiltration is crucial for developing more effective immunotherapies.