Publications by authors named "W Grajkowska"
Purpose: This study aimed to summarize the existing English-language literature on central nervous system (CNS) meningeal melanocytomas in children, and additionally describe our institutional case report.
Methods: PubMed database was screened on September 2, 2024, for English-language papers reporting on pediatric patients with CNS meningeal melanocytoma.
Results: A total of 17 papers reporting on 18 patients with 19 CNS meningeal melanocytomas were found in the literature.
Transcription factors are frequent cancer driver genes, exhibiting noted specificity based on the precise cell of origin. We demonstrate that ZIC1 exhibits loss-of-function (LOF) somatic events in group 4 (G4) medulloblastoma through recurrent point mutations, subchromosomal deletions and mono-allelic epigenetic repression (60% of G4 medulloblastoma). In contrast, highly similar SHH medulloblastoma exhibits distinct and diametrically opposed gain-of-function mutations and copy number gains (20% of SHH medulloblastoma).
View Article and Find Full Text PDFBackground: Multiparametric MRI markers of liver health corrected T1 (cT1) and proton density fat fraction (PDFF) have shown utility in the management of various chronic liver diseases. We assessed the normal population reference range of both cT1 and PDFF in healthy child and adult volunteers without any known liver disease.
Methods: A retrospective multi-centre pooled analysis of 102 child and young adult (9.
CIC fusions have been described in two different central nervous system (CNS) tumor entities. On one hand, fusions of CIC or ATXN1 genes belonging to the same complex of transcriptional repressors, were reported in the CIC-rearranged, sarcoma (SARC-CIC). The diagnosis of this tumor type, which was recently added to the World Health Organization (WHO) Classification of CNS tumors, is difficult mainly because the data concerning its histopathology (as compared to its soft tissue counterpart), immunoprofile, and clinical as well as radiological characteristics are scarce in the literature.
View Article and Find Full Text PDFArticle Synopsis
- Rhabdomyosarcoma (RMS) of the biliary tract is a rare pediatric cancer, accounting for only 0.5-0.8% of all RMS cases in children, yet it is the most common malignancy in this area for that age group.
- The study analyzed the medical records of eight children treated for biliary tract RMS between 1996-2022, focusing on symptoms, diagnoses, treatment approaches, and outcomes.
- Among the patients, initial symptoms included jaundice, with treatment involving biopsy, chemotherapy, and surgery; 75% of the patients are currently alive with no disease progression after a median follow-up of over 11 years.