Publications by authors named "W Gower"
Article Synopsis
- The SFTPC gene mutation (SFTPCI73T) is a major cause of interstitial lung disease, leading to limited treatment options.
- Research shows that EMC3 is crucial for maintaining surfactant balance in alveolar type 2 cells and influences the metabolism of the SFTPCI73T mutation.
- Findings indicate that deleting Emc3 can improve lung structure and function in mice with the SFTPCI73T mutation, revealing new therapeutic targets, particularly involving Valosin Containing Protein (VCP) for treatment.
Background: Asthma and obesity are frequent outcomes among individuals born extremely preterm and are associated with decreased lifespan. Neonatal inflammation is associated with chronic neurodevelopmental disorders; however, it is less studied in association with other later childhood chronic disorders in this population.
Methods: Fourteen hospitals in 5 U.
Hematopoietic stem cell transplantation (HSCT) is undertaken in children with the aim of curing a range of malignant and nonmalignant conditions. Unfortunately, pulmonary complications, especially bronchiolitis obliterans syndrome (BOS), are significant sources of morbidity and mortality post-HSCT. Currently, criteria developed by a National Institutes of Health (NIH) working group are used to diagnose BOS in children post-HSCT.
View Article and Find Full Text PDFMany children undergo allogeneic hematopoietic stem cell transplantation (HSCT) for the treatment of malignant and nonmalignant conditions. Unfortunately, pulmonary complications occur frequently post-HSCT, with bronchiolitis obliterans syndrome (BOS) being the most common noninfectious pulmonary complication. Current international guidelines contain conflicting recommendations regarding post-HSCT surveillance for BOS, and a recent NIH workshop highlighted the need for a standardized approach to post-HSCT monitoring.
View Article and Find Full Text PDFBackground: Little is known about the role of air quality in fatal asthma exacerbations among children.
Methods: We collected information about 80 deaths that occurred in North Carolina from 2001 through 2016, among children aged 5-17 years, with asthma identified as the primary cause of death. We linked information about each death with county-level estimates of particulate matter ≤2.