Publications by authors named "W G Webber"
Introduction: Interleukin-18 (IL-18), a pro-inflammatory cytokine belonging to the IL-1 Family, is a key mediator ofautoinflammatory diseases associated with the development of macrophage activation syndrome (MAS).High levels of IL-18 correlate with MAS and COVID-19 severity and mortality, particularly in COVID-19patients with MAS. As an inflammation inducer, IL-18 binds its receptor IL-1 Receptor 5 (IL-1R5), leadingto the recruitment of the co-receptor, IL-1 Receptor 7 (IL-1R7).
View Article and Find Full Text PDFWe previously reported that pan-cortical effects occur when cognitive tasks end afterdischarges. For this report, we analyzed wavelet cross-coherence changes during cognitive tasks used to terminate afterdischarges studying multiple time segments and multiple groups of inter-electrode-con distances. We studied 12 patients with intractable epilepsy, with 970 implanted electrode contacts, and 39,871 electrode contact combinations.
View Article and Find Full Text PDFArticle Synopsis
- IL-38 is primarily known as an anti-inflammatory cytokine but also acts as a growth factor in the murine small intestine (SI), promoting organoid size through WNT3a.
- In IL-38-deficient mice, organoids develop more slowly due to decreased expression of intestinal stemness markers, indicating IL-38's role in supporting stem cell properties.
- While IL-1R9's involvement in IL-38 signaling remains uncertain, silencing of IL-1R6 impairs the growth response to IL-38, suggesting IL-1R6 is the main receptor for IL-38 in intestinal stem cell regulation.
Objective: We previously studied efficacy of cognitive tasks on afterdischarge termination in patients undergoing cortical stimulation and found that diffuse wavelet cross-coherence changes on electrocorticography were associated with termination efficacy. We now report wavelet cross-coherence findings during different time segments of trials during which afterdischarges ended.
Methods: For 12 patients with implanted subdural electrodes, we compared wavelet cross-coherence findings among several 1-second portions of cognitive tasks, reflecting task presentation, patient replies, and afterdischarge termination.