Publications by authors named "W G Mantyh"
Introduction: Little is known about the factors underpinning discordant cerebrospinal fluid (CSF) amyloid beta (Aβ) versus p-tau181/Aβ or CSF Aβ versus Aβ positron emission tomography (PET).
Methods: We stratified 570 non-demented Alzheimer's Disease Neuroimaging Initiative (ADNI) participants by Aβ PET and further by CSF Aβ or p-tau181/Aβ. We used analysis of covariance testing adjusting for covariates, followed by Tukey post hoc pairwise comparisons, to compare CSF soluble triggering receptor expressed on myeloid cells-2 (sTREM2) across four participant groups: CSF+ with CSF- , CSF- with CSF+ , and concordant CSF/CSF.
Article Synopsis
- Cockayne syndrome (CS) is a rare genetic disorder causing premature aging and various neurological issues, but the clinical features of neurodegeneration, especially in later stages, are not well understood.
- A study examined medical records of individuals with CS who lived beyond 18 years across three countries to identify common neurological complications, finding that most showed significant neurocognitive and physical decline.
- Results indicated that nearly all participants experienced neurocognitive/neuropsychiatric symptoms, with high rates of tremors, peripheral neuropathy, and observable brain atrophy, suggesting a link between DNA repair defects in CS and broader neurodegenerative processes.
Objectives: frequency varies by geography and ancestry. We provide data regarding the frequency of this allele in the Ojibwe people, the fifth largest Indigenous people in the United States.
Methods: Population study including 33 cognitively normal older individuals of an Ojibwe Tribal Nation (total population: 984; all with ≥25% Ojibwe ancestry).
Non-pharmaceutical interventions (NPI) have great potential to improve cognitive function but limited investigation to discover NPI repurposing for Alzheimer's Disease (AD). This is the first study to develop an innovative framework to extract and represent NPI information from biomedical literature in a knowledge graph (KG), and train link prediction models to repurpose novel NPIs for AD prevention. We constructed a comprehensive KG, called ADInt, by extracting NPI information from biomedical literature.
View Article and Find Full Text PDF