Publications by authors named "W G Honer"
Article Synopsis
- The aging brain's cognitive abilities are influenced by a balance between protective lifestyles and the accumulation of brain pathologies, especially in Alzheimer's disease.
- A study involving 440 participants used advanced methods to analyze the relationships between physical activity, cognitive function, and specific brain changes after death.
- Key findings revealed that synaptic peptides are critical for understanding cognitive decline, with lower physical activity linked to greater negative impacts between tau pathology and synaptic health in older adults.
Background: The pathophysiology of protracted symptoms after COVID-19 is unclear. This study aimed to determine if long-COVID is associated with differences in baseline characteristics, markers of white matter diffusivity in the brain, and lower scores on objective cognitive testing.
Methods: Individuals who experienced COVID-19 symptoms for more than 60 days post-infection (long-COVID) (n = 56) were compared to individuals who recovered from COVID-19 within 60 days of infection (normal recovery) (n = 35).
Background: Severe psychomotor agitation and aggression often require immediate pharmacological intervention, but clear evidence-based recommendations for choosing among the multiple options are lacking. To address this gap, we plan a systematic review and individual-participant-data network meta-analysis to investigate their comparative effectiveness in real-world emergency settings with increased precision.
Methods: We will include randomized controlled trials investigating intramuscular or intravenous pharmacological interventions, as monotherapy or in combination, in adults with severe psychomotor agitation irrespective of the underlying diagnosis and requiring rapid tranquilization in general or psychiatric emergency settings.
Objective: To examine the relationship between schizophrenia, antipsychotic medication adherence and driver responsibility for motor vehicle crash.
Design: Retrospective observational cohort study using 20 years of population-based administrative health and driving data.
Setting: British Columbia, Canada.
In the rodent, hippocampal neurogenesis plays critical roles in learning and memory, is tightly regulated by inhibitory neurons and contributes to memory dysfunction in Alzheimer's disease (AD) mouse models. In contrast, the mechanisms regulating neurogenesis in the adult human hippocampus, the dynamic shifts in the transcriptomic and epigenomic profiles in aging and AD and putative niche interactions within the cellular environment, remain largely unknown. Using single nuclei multi-omics of postmortem human hippocampi we map the molecular mechanisms of hippocampal neurogenesis across aging, cognitive decline, and AD neuropathology.
View Article and Find Full Text PDF