Publications by authors named "W G HANSEN"
This report details the case of a 29-year-old male patient who presented at a tertiary-level trauma centre with multiple stab wounds to the face, chest, and back. Despite not undergoing surgical intervention or exhibiting any apparent cerebrospinal fluid (CSF) leakage during the initial evaluation. The patient's condition deteriorated, with subsequent cultures from CSF and blood confirmed extensively drug-resistant (XDR) Acinetobacter baumannii (A.
View Article and Find Full Text PDFBackground: Muscarinic receptor agonism and positive allosteric modulation is a promising mechanism of action for treating psychosis, not present in most D2R-blocking antipsychotics. Xanomeline, an M1/M4-preferring agonist, has shown efficacy in late-stage clinical trials, with more compounds being investigated. Therefore, we aim to synthesize evidence on the preclinical efficacy of muscarinic receptor agonists and positive allosteric modulators in animal models of psychosis to provide unique insights and evidence-based information to guide drug development.
View Article and Find Full Text PDFArticle Synopsis
- Cognitive deficits significantly impact individuals with schizophrenia spectrum disorders (SSDs), and while antipsychotics are commonly used, they don’t enhance cognition and vary in their effectiveness based on their receptor profiles.
- The study aimed to assess the relationship between various antipsychotic treatments and cognitive performance in SSD patients by analyzing numerous randomized clinical trials.
- Findings showed that while no specific antipsychotic consistently performed better than placebo in improving cognition, collectively, antipsychotics had a small positive effect on cognitive outcomes compared to no treatment.
Background: The discrepancy between experimental research and clinical trial outcomes is a persistent challenge in preclinical studies, particularly in stroke research. A possible factor contributing to this issue is the lack of standardization across experimental stroke models, leading to poor reproducibility in multicenter studies. This study addresses this gap by aiming to enhance reproducibility and the efficacy of multicenter studies through the harmonization of protocols and training of involved personnel.
View Article and Find Full Text PDFPurpose: A model is proposed in which longitudinal changes in adolescents' dispositions increase age-related risk for the onset of substance use.
Method: Pooled surveys from 25 longitudinal studies were examined. Disposition was calculated from eight variables: use intentions; refusal intentions; attitudes; positive consequence beliefs; beliefs about negative consequences; descriptive peer normative beliefs; injunctive peer normative beliefs; and lifestyle incongruence.