Publications by authors named "W Fleischmann"
Article Synopsis
- The Prime-2-CoV_Beta is a new COVID-19 vaccine designed to target the SARS-CoV-2 spike and nucleocapsid antigens, and was tested in a phase I clinical trial involving 60 healthy adults in Germany from June 2022 to June 2023.
- The trial showed that the vaccine had a good safety profile with only mild to moderate side effects, such as pain at the injection site, fatigue, and headache, and no serious adverse events were reported.
- Immunization resulted in strong immune responses, particularly at higher doses, leading to significant increases in antibodies against SARS-CoV-2 and its variants, indicating the vaccine's potential for broader protection
Article Synopsis
- Human immune responses to infections like malaria are influenced by genetics, environment, and past infections, but the role of latent cytomegalovirus (CMV) in malaria immunity is not well understood.
- Research examined how CMV affects immune responses to malaria using samples from prior clinical trials, revealing that CMV seropositivity leads to lower production of specific antibodies after malaria infection and vaccination, and alters Tfh cell responses.
- The study indicates that individuals with CMV are less likely to develop protective antibodies against malaria, highlighting the need for further research in malaria-endemic areas to understand how CMV might affect immunity in children.
Article Synopsis
- - The rise of autochthonous tropical diseases in Europe is tied to climate change, which is affecting the distribution and activity of disease-carrying vectors like mosquitoes and ticks.
- - Notable species like Aedes albopictus and Aedes aegypti have created stable populations in Europe, leading to increased cases of diseases such as dengue fever and West Nile virus in previously unaffected temperate areas.
- - To combat these emerging health threats, experts recommend enhancing disease surveillance, developing weather-related predictive models, and improving vector control strategies to safeguard public health against the effects of climate change.
Following a 2-week trip to Kazakhstan, a 42-year-old woman presented at the emergency department in Germany with fever, headache, nausea, and neurological symptoms. An infection with Plasmodium falciparum was rapidly diagnosed. The patient was immediately treated with intravenous artesunate and transferred to an intensive care unit.
View Article and Find Full Text PDFBackground: Dengue is one of the most common diseases in the tropics and subtropics. Whilst mortality is a rare event when adequate supportive care can be provided, a large number of patients get hospitalised with dengue every year that places a heavy burden on local health systems. A better understanding of the support required at the time of hospitalisation is therefore of critical importance for healthcare planning, especially when resources are limited during major outbreaks.
View Article and Find Full Text PDF