Concordance of indirect methods for the detection of lactose malabsorption in diabetic and nondiabetic subjects.

In order to collect data on (1) the prevalence of lactose malabsorption and (2) the value of indirect diagnostic methods for hypolactasia in diabetics, we compared lactose tolerance tests using serum glucose, serum galactose (after oral ethanol intake) and breath hydrogen excretion as diagnostic cutoff in 144 nondiabetic and 46 diabetic subjects. A good rate of concordance was found for the hydrogen breath test and galactose-dependent lactose tolerance test. The glucose-dependent lactose tolerance test was found to be of satisfactory diagnostic value in nondiabetic subjects and was useless for diagnostic purposes in diabetics.

The effect of an osmotic stimulus on the release of neurohypophysial hormones in the cat: preferential release of vasopressin with a possible involvement of the area postrema.

Abstract In cats anaesthetized with intravenous chloralose, the injection of 0.05 to 0.4 ml 1.

Blood pressure effects of leptazol applied to the ventral surface of the brain stem of cats.

In anaesthetized cats leptazol (200 mg/ml) and sodium pentobarbitone (30 mg/ml) were applied topically to an area of the exposed ventral surface of the medulla oblongata, which lies between the rootlets of the twelfth cranial and first cervical nerve. The drugs were applied either bilaterally by means of paired Perspex rings or unilaterally by means of a single Perspex ring. Their effects on arterial blood pressure, heart rate and respiration were examined during two stages of anaesthesia, during 'surgical anaesthesia' produced by an intravenous injection of chloralose at 60 mg/kg, and during deeper anaesthesia attained by two additional intravenous injections of chloralose at 30 mg/kg.

Analysis of cardiovascular effects of morphine in the cat.

In cats anaesthetized with chloralose, the effect of morphine on arterial blood pressure and heart rate was examined by injecting the drug through different routes. When injected into the cerebral ventricles, it acted on structures in the walls of the third ventricle and produced a naloxone resistant tachycardia through a sympathetic discharge to the heart. When injected into the cisterna magna or subcutaneously, it produced a naloxone sensitive long-lasting fall in blood pressure and bradycardia resulting from inhibition of sympathetic tone to blood vessels and heart; increased vagal tone played a minor role in the development of bradycardia.