Hepatic arterial infusion chemotherapy combined with immune checkpoint inhibitors and molecular targeted therapies for advanced infiltrative hepatocellular carcinoma: a single-center experience.

Background: Infiltrative hepatocellular carcinoma (HCC) remains a therapeutic challenge due to its aggressive course and poor prognosis. Hepatic arterial infusion chemotherapy (HAIC) plus immune checkpoint inhibitors (ICIs) and molecular targeted therapies (MTTs) has shown early promise for advanced HCC, but its role in advanced infiltrative HCC is unclear. This study aims to investigate the efficacy and safety of HAIC combined with ICIs and MTTs in the treatment of advanced infiltrative HCC.

Physics-informed Neural Implicit Flow neural network for parametric PDEs.

The Physics-informed Neural Network (PINN) has been a popular method for solving partial differential equations (PDEs) due to its flexibility. However, PINN still faces challenges in characterizing spatio-temporal correlations when solving parametric PDEs due to network limitations. To address this issue, we propose a Physics-Informed Neural Implicit Flow (PINIF) framework, which enables a meshless low-rank representation of the parametric spatio-temporal field based on the expressiveness of the Neural Implicit Flow (NIF), enabling a meshless low-rank representation.

Strength Tests and Mechanism of Composite Stabilized Lightweight Soil Using Dredged Sludge.

To achieve resourceful utilization of dredged sludge, lightweight treatment was performed on sludge from Xunsi River in Wuhan using fly ash, cement, and expanded polystyrene (EPS) particles. Density tests and unconfined compressive strength (UCS) tests were conducted on the composite stabilized sludge lightweight soil to determine the optimal mix ratio for high-quality roadbed fill material with low self-weight and high strength. Subsequently, microstructural tests, including X-ray diffraction (XRD) and scanning electron microscopy (SEM), were conducted.

Degenerative Disease Diagnosis and Analysis Based on Tissue Specificity of DNA Methylation.

The tissue specificity of DNA methylation refers to the significant differences in DNA methylation patterns in different tissues. This specificity regulates gene expression, thereby supporting the specific functions of each tissue and the maintenance of normal physiological activities. Abnormal tissue-specific patterns of DNA methylation are closely related to age-related diseases.

Bioremediation of Heavy Metal-Contaminated Solution and Aged Refuse by Microbially Induced Calcium Carbonate Precipitation: Further Insights into .

Recently, the ability of microbial-induced calcium carbonate precipitation (MICP) to remediate heavy metals has been widely explored. was selected to remediate heavy metal-contaminated solution and aged refuse, exploring the feasibility of bioremediation of heavy metals and analyzing the changes in heavy metal forms before and after bioremediation, as well as the mechanism of remediation. The results showed that achieved remediation rates of 95%, 84%, 97%, and 98% for Cd, Pb, Zn, and Cr (III) in contaminated solution, respectively.