Publications by authors named "W F Pritchard"
Intratumoral injections often lack visibility, leading to unpredictable outcomes such as incomplete tumor coverage, off-target drug delivery and systemic toxicities. This study investigated an ultrasound (US) and x-ray imageable thermosensitive hydrogel based on poloxamer 407 (POL) percutaneously delivered in a healthy swine model. The primary objective was to assess the 2D and 3D distribution of the hydrogel within tissue across three different needle devices and injection sites: liver, kidney, and intercostal muscle region.
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- * Researchers created computational phantoms with different sizes and materials (iodine and gadolinium) and imaged them under various settings to evaluate signal quality using spectral-specific metrics like multivariate CNR and separability index.
- * Findings revealed optimal signal quality occurred with low energy thresholds, high tube currents, and small phantoms, while a random forest algorithm showed the best performance in accurately identifying materials across the different conditions tested.
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- This study developed an algorithm that creates a referenceable bladder map from standard cystoscopy videos, allowing diagnosis and monitoring of bladder carcinoma without needing advanced equipment.
- The algorithm generates 2D bladder maps by stitching together frames from cystoscopy videos by matching surface features, and it was tested on both swine and archived clinical videos.
- Results showed high performance with 93-99% of frames suitable for creating bladder maps, useful for recording pathology and treatment areas, especially in cases of recurrent bladder cancer or in low-resource environments.
Intratumoral injections often lack visibility, leading to unpredictable outcomes such as incomplete tumor coverage, off-target drug delivery and systemic toxicities. This study investigated an ultrasound (US) and x-ray imageable thermosensitive hydrogel based on poloxamer 407 (POL) percutaneously delivered in a healthy swine model. The primary objective was to assess the 2D and 3D distribution of the hydrogel within tissue across three different needle devices and injection sites: liver, kidney, and intercostal muscle region.
View Article and Find Full Text PDFTransarterial chemoembolization (TACE) is an image-guided minimally invasive treatment for liver cancer which involves delivery of chemotherapy and embolic material into tumor-supplying arteries to block blood flow to a liver tumor and to deliver chemotherapy directly to the tumor. However, the released drug diffuses only less than a millimeter away from the beads. To enhance the efficacy of TACE, the development of microbubbles electrostatically bound to the surface of drug-eluting beads loaded with different amounts of doxorubicin (0-37.
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