Background: Recently, deep convolutional neural networks (CNNs) have shown great potential in medical image classification tasks. However, the practical usage of the methods is constrained by two challenges: 1) the challenge of using nonindependent and identically distributed (non-IID) datasets from various medical institutions while ensuring privacy, and 2) the data imbalance problem due to the frequency of different diseases.
Purpose: The objective of this paper is to present a novel approach for addressing these challenges through a decentralized learning method using a prototypical contrastive network to achieve precise medical image classification while mitigating the non-IID problem across different clients.
Neonatal hypoxia-ischemia (HI) brain injury is considered a major cause of neonatal mortality and chronic disease morbidity worldwide. Despite its clinical importance, therapeutic options for HI injury remain limited. Here we demonstrated that miR-34c-5p expression peaks at postnatal day 10 in mice.
View Article and Find Full Text PDFThis study aimed to investigate the potential reduction on the sensitization of sesame protein Ses i 3 through ultrasound-assisted glycation. Ses i 3 was extracted and purified using an immunoaffinity column, and the allergenicity changes of Ses i 3 were assessed by a comprehensive strategy, and T cell polarization was also assessed in vivo. Results showed ultrasound-assisted glycation treated Ses i 3 was more easily digestible; and the cell degranulation model showed the histamine, tryptase, and β-hexosaminidase induced by ultrasound-assisted glycation treatment were significantly decreased; besides, the serological results demonstrated that a notable decrease in the binding ability of immunoglobulin E (IgE) and IgG; finally, a BALB/c mice model demonstrated an alleviation of allergic responses induced by ultrasonic-assisted glycation treatment.
View Article and Find Full Text PDFEthnopharmacological Relevance: Zuojin Pill (ZJP) is a traditional Chinese medicine (TCM) formula composed of Coptidis Rhizoma and Euodiae Fructus in a ratio of 6:1 (w/w), which has been widely used for treating gastrointestinal disorders, especially stomach heat syndrome (SHS). However, the active alkaloids in ZJP showed low plasma exposure in rats following oral administration, which failed to explain their potent pharmacological effects, thereby limiting further mechanism studies.
Aim Of The Study: This study aimed to investigate the in vivo exposure and tissue distribution propensities of the active alkaloids in normal and SHS rats following oral administration of ZJP.
The present study investigated the richness and diversity of vaginal microbiota among a cohort of 60 childbearing-age women. The samples were classified into three groups: healthy control (HC), bacterial vaginosis (BV), and BV intermediate (BVI). The number of Operational Taxonomic Units (OTUs) per sample ranged from 50 to 212, with three groups having 469 (HC), 482 (BVI), and 456 (BV) OTUs.
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