Absence of disulfiram-type reactions to single and multiple doses of cefonicid: a placebo-controlled study.

Disulfiram-type reactions after ingestion of alcohol have been reported in patients treated with a number of cephalosporin antibiotics; predominantly with agents containing the methylthiotetrazole side chain, although other similar configurations have also been implicated. Since cefonicid has a sulphonic acid thiotetrazole substitution, we investigated the possibility of a cefonicid-ethanol interaction in 15 healthy volunteers. During the first two crossover phases of the study, single 1 g doses of cefonicid followed by ethanol challenges were compared to placebo followed by ethanol challenges.

Appraisal of modifiable hospitalization risks.

Nine prevention experts rated hospitalization risks of 64 hypothetical healthy adults between 20 and 65 years old. There was substantial agreement among seven out of the nine experts. Pairwise correlations between any two of the experts ranged between 0.

Computerized tomographic abnormalities in patients with transient episodes of focal neurological dysfunction.

Forty patients with episodes of transient neurological dysfunction lasting less than 24 hr had abnormal CT scan findings. Eight patients had intracranial mass lesions and 32 had vascular lesions i.e.

Enhancing cerebellar infarction.

Five patients with CT evidence of enhancing cerebellar infarcts are analyzed. This represented 12% of cerebellar infarcts diagnosed by CT scan. The pattern of cerebellar linear enhancing bands which are contiguous with a hypo- or isodense lesion is quite characteristic of cerebellar infarction.