Measurement of reoxygenation during fractionated radiotherapy in head and neck squamous cell carcinoma xenografts.

Hypoxic tissues lack adequate oxygenation and it has been long established that tumours commonly exhibit hypoxia and that hypoxia is a factor contributing towards resistance to radiotherapy. To develop computer models and make predictions about the affects of tumour hypoxia on treatment outcome, quantitative tumour oxygenation and reoxygenation data from in vivo systems is required. The aim of this study was to investigate the timing and degree of reoxygenation during radiotherapy in a human head and neck squamous cell carcinoma xenograft mouse model (FaDu).

Transluminal angioplasty of the iliac artery combined with femorofemoral bypass.

Significant aortoiliac occlusive disease commonly occurs in patients who are not acceptable risks for conventional aortoiliac or aortofemoral bypass reconstruction. We propose that, in suitable candidates, the lower extremities can be revascularized by combining intraluminal angioplasty of stenotic iliofemoral segments with femorofemoral bypass graft. We present three patients who have been managed in this fashion with satisfactory results.