Stroke of Consistency: Streamlining Multicenter Protocols for Enhanced Reproducibility of Infarct Volumes in Preclinical Stroke Research.

Background: The discrepancy between experimental research and clinical trial outcomes is a persistent challenge in preclinical studies, particularly in stroke research. A possible factor contributing to this issue is the lack of standardization across experimental stroke models, leading to poor reproducibility in multicenter studies. This study addresses this gap by aiming to enhance reproducibility and the efficacy of multicenter studies through the harmonization of protocols and training of involved personnel.

Modeling Adolescent Disposition Development: Age-Related Changes in Psychosocial Processes Correlated with Substance Use.

Purpose: A model is proposed in which longitudinal changes in adolescents' dispositions increase age-related risk for the onset of substance use.

Method: Pooled surveys from 25 longitudinal studies were examined. Disposition was calculated from eight variables: use intentions; refusal intentions; attitudes; positive consequence beliefs; beliefs about negative consequences; descriptive peer normative beliefs; injunctive peer normative beliefs; and lifestyle incongruence.

Psychological interventions for early-phase schizophrenia: protocol for a systematic review and network meta-analysis.

Introduction: Treating the early phase of schizophrenia is crucial for preventing further episodes and improving quality of life, functioning, and social inclusion. Pharmacotherapies are first-line treatments, but have limitations. There is consensus on the need for non-pharmacological interventions for individuals in the early phase of schizophrenia.

Parameters of 150 temperate and boreal tree species and provenances for an individual-based forest landscape and disturbance model.

Understanding the impacts of changing climate and disturbance regimes on forest ecosystems is greatly aided by the use of process-based models. Such models simulate processes based on first principles of ecology, which requires parameterization. Parameterization is an important step in model development and application, defining the characteristics of trees and their responses to the environment, i.