Publications by authors named "W F GONZALEZ"
Anterior cruciate ligament reconstruction (ACLR), despite its effectiveness in restoring knee stability and function, can have associated morbidity. The most frequent complications are technical errors, which have been described during graft harvesting, tunnel placement or graft fixation. The most serious complications are neurovascular injuries, arthrofibrosis and infections.
View Article and Find Full Text PDFHost-microbe computational proteomic landscape in oral cancer revealed key functional and metabolic pathways between Fusobacterium nucleatum and cancer progression.
Int J Oral Sci
January 2025
Oral squamous cell carcinoma (OSCC) is the most common manifestation of oral cancer. It has been proposed that periodontal pathogens contribute to OSCC progression, mainly by their virulence factors. However, the main periodontal pathogen and its mechanism to modulate OSCC cells remains not fully understood.
View Article and Find Full Text PDFConstitutive sodium permeability in a two-pore domain potassium channel.
Proc Natl Acad Sci U S A
October 2024
Article Synopsis
- Two-pore domain potassium (K2P) channels are crucial for regulating how cells respond to stimuli and function in the nervous system, and their selectivity filter structure is key to their ability to selectively allow potassium ions to pass.
- The nematode has a large family of K2P channels with 47 genes, and this study focuses on the UNC-58 channel which is uniquely permeable to sodium ions due to a specific cysteine in its selectivity filter.
- Through various experimental methods, the researchers found that UNC-58 causes depolarization in muscles and sensory neurons, leading to hypercontracted outcomes in gain-of-function mutants, highlighting the necessity of functional studies to understand how variations in selectivity filter sequences affect
Background: Understanding antibody responses to SARS-CoV-2 vaccination is crucial for refining COVID-19 immunization strategies. Generation of mucosal immune responses, including mucosal IgA, could be of potential benefit to vaccine efficacy; however, limited evidence exists regarding the production of mucosal antibodies following the administration of current mRNA vaccines to young children.
Methods: We measured the levels of antibodies against SARS-CoV-2 from a cohort of children under 5 years of age (n = 24) undergoing SARS-CoV-2 mRNA vaccination (serially collected, matched serum and saliva samples) or in a convenience sample of children under 5 years of age presenting to pediatric emergency department (nasal swabs, n = 103).
Introduction: Edentulism is the partial or total loss of teeth, it is irreversible and disabling due to its sequelae in the masticatory, phonetic and aesthetic function that affect the quality of life.
Objective: To establish the impact of edentulism and sociodemographic factors on the quality of life of the Salvadoran population.
Materials And Methods: Secondary cross-sectional analysis of data in 3322 users of the Public Health System of El Salvador, aged 15 to > 60 years.