Publications by authors named "W F Doolittle"
Science offers the best way of knowing-as long as we don't confuse what "is" with what "ought to be".
Proc Natl Acad Sci U S A
October 2024
The density of tumor-associated macrophages in the tumor microenvironment of anaplastic thyroid cancer (ATC) is associated with poor prognosis. However, the crosstalk between macrophages and ATC cells is poorly understood. This study aimed to examine the impact of macrophages on cancer cell phenotypes.
View Article and Find Full Text PDFAnaplastic thyroid cancer (ATC) is highly aggressive and has very limited treatment options. Recent studies suggest that cancer stem cell (CSC) activity in ATC could underlie this recurrence and resistance to treatment. The recent approval by the U.
View Article and Find Full Text PDFArticle Synopsis
- Thyroid hormone receptor α1 (TRα1) plays a significant role in mediating the effects of thyroid hormones, but its function in thyroid cancers, particularly anaplastic thyroid cancer (ATC), is not fully understood.
- Research using The Cancer Genome Atlas (TCGA) revealed that THRA gene expression is lost in highly aggressive ATC, leading to experiments where TRα1 was stably expressed in ATC cell lines, showing it inhibited cell growth and induced cell death.
- Furthermore, TRα1 was found to regulate the expression of paired box gene 8 (PAX8), which is linked to thyroid differentiation, suggesting TRα1 could be targeted for therapy to improve outcomes in ATC patients by promoting