The effect of morphine on uptake of serotonin into hypothalamic synaptosomes was determined following acute and chronic morphine treatment in the rat. The uptake of serotonin was noncompetitively inhibited by in vitro morphine (IC50 = 7 X 10(-4) M) but not by an acute morphine treatment (30 mg/kg s.c.
View Article and Find Full Text PDFToxicol Appl Pharmacol
January 1977
Commun Psychopharmacol
April 1978