Publications by authors named "W Elias"
The functions of bacterial plasmid-encoded toxin-antitoxin (TA) systems are unambiguous in the sense of controlling cells that fail to inherit a plasmid copy. However, its role in chromosomal copies is contradictory, including stress-response-promoting fitness and antibiotic treatment survival. A hybrid pathogenic strain may have the ability to colonize distinct host niches, facing contrasting stress environments.
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- The study focused on EC092, a strain of bacteria isolated from bloodstream infections that shows hybrid pathogenic potential due to its enteroaggregative (EAEC) genetic markers.
- Whole-genome sequencing identified EC092 as belonging to phylogroup B1, ST278, and serotype O165:H4, revealing several genes associated with virulence factors, including fimbriae and toxins.
- The strain EC092 was found to have a similar virulence profile to some EAEC strains linked to diarrhea and is capable of causing infections outside the intestines, indicating its dual pathogenic capabilities.
The unprecedented use of high-resolution continuum source molecular absorption spectrometry (HR-CS MAS) for the fractionation of organic and inorganic sulfur (S) species through monitoring the CS molecule is presented here. Two separate methods for determining organic (CS) and inorganic (CS) sulfur were developed to work sequentially. The optimized temperature program for both methodologies has two pyrolysis steps and one vaporization step (1st T: 1800 and 2T: 800 °C, and T: 2500 °C).
View Article and Find Full Text PDFBackground: There remains high variability in clinical outcomes when the same magnetic resonance image-guided focused ultrasound (MRgFUS) thalamotomy target is used for both essential tremor (ET) and tremor-dominant Parkinson's disease (TDPD).
Objective: Our goal is to refine the MRgFUS thalamotomy target for TDPD versus ET.
Methods: We retrospectively performed voxel-wise efficacy and structural connectivity mapping using 3-12-month post-procedure hand tremor scores for a multicenter cohort of 32 TDPD patients and a previously published cohort of 79 ET patients, and 24-hour T1-weighted post-MRgFUS brain images.
Importance: Unilateral magnetic resonance-guided focused ultrasound ablation of ventralis intermedius nucleus of the thalamus for essential tremor reduces tremor on 1 side, but untreated contralateral or midline symptoms remain limiting for some patients. Historically, bilateral lesioning produced unacceptable risks and was supplanted by deep brain stimulation; increasing acceptance of unilateral focused ultrasound lesioning has led to interest in a bilateral option.
Objective: To evaluate the safety and efficacy of staged, bilateral focused ultrasound thalamotomy.