Tumour budding, uPA and PAI-1 are associated with aggressive behaviour in colon cancer.

Aims: The proteases PAI-1 and uPA play a major role in extracellular matrix degradation, which facilitates tumour progression. Tumour budding is a histomorphological expression of enhanced tumour cell migration.

Materials And Methods: To investigate their prognostic value for and correlation with colon cancer, a prospective study was performed.

[Impending Coumarin-necrosis in a patient with heterozygous protein C deficiency type I].

Painful pink or magenta colored skin lesions characterized by a clear line of demarcation between the affected area and surrounding tissue appearing under therapy with coumarins may be a sign for evolving coumarin-necrosis. Immediate treatment with a protein C preparation in patients with protein C deficiency can prevent necrosis.

[Meningitis caused by Streptococcus suis].

History And Admission Findings: A 42-year-old man was admitted to hospital because of headache and fever for two days and showing signs of meningism. As a butcher he had had frequent cuts on his hands and forearms.

Investigations And Diagnosis: Analysis of the cerebrospinal fluid revealed an elevated leukocyte count (81% segmented neutrophils).

[Interdisciplinary diagnostics in the outpatient treatment department of an environmental medical centre - report on experience with 400 patients].

The medical diagnostics of 400 patients of an interdisciplinary environmental medical centre is presented. The basic diagnostics included a special environmental medical history using a questionnaire, physical examination, allergological examinations and human biomonitoring. The latter was carried out in order to quantify the internal exposure to environmental pollutants.

[Pyrethroid exposure following indoor treatments with a dog flea powder].

Unlabelled: Pyrethroid exposure following indoor treatments with a dog flea powder.

History: A 42 year old woman reported hair loss, gastrointestinal and non-specific symptoms. The patient has lived in a council flat and kept a dog who had been regularly treated with pyrethroid containing flea powder.