Publications by authors named "W E Zimmermann"
Background: CEACAM1 in leukocytes controls cell activation during inflammation. This and its expression in epithelial cells led to frequent independent appropriation of CEACAM1 as receptor by pathogens in humans and other species to gain host access and to downregulate its immune response. As a countermeasure, decoy receptors with CEACAM1-like pathogen-binding domains evolved.
View Article and Find Full Text PDFHeart failure (HF) remains a leading cause of mortality, responsible for 13% of all deaths worldwide. The prognosis for patients with HF is poor, with only a 50% survival rate within 5 years. A major challenge of ischaemia-driven HF is the loss of cardiomyocytes, compounded by the minimal regenerative capacity of the adult heart.
View Article and Find Full Text PDFThere is a paucity of sport-specific safety data on high diving. This paper describes the results of a survey of all athletes competing in elite international competitions between 2009 and 2021.Sixty-eight athletes completed surveys, representing a response rate of 80%.
View Article and Find Full Text PDFArticle Synopsis
- Evolutionary changes in RNA translation rates and new genes, including small open reading frames, play a key role in the development of innovations in primates and rodents.
- This study examined the hearts of four primate species and two rodent species using advanced ribosome and transcriptomic profiling techniques, focusing on adult heart tissues and stem cell-derived heart cells.
- Findings revealed rapid evolution in the translation efficiency of mitochondrial complexes and identified numerous unique genomic features related to primate heart evolution, highlighting mechanisms that influence cardiac development and potential disease.