Dementia Care Practice.

Background: Uganda has an increasing population of older persons who require special attention to reduce the burden of dementia. With the growing prevalence of dementia worldwide, two third of the people with dementia are projected to be from the de-eloping countries by 2050. Few studies have been conducted on the prevalence of dementia and its association with central nervous system (CNS) infections among older persons in African settings, particularly in Uganda.

Efficient scaling of large language models with mixture of experts and 3D analog in-memory computing.

Large language models (LLMs), with their remarkable generative capacities, have greatly impacted a range of fields, but they face scalability challenges due to their large parameter counts, which result in high costs for training and inference. The trend of increasing model sizes is exacerbating these challenges, particularly in terms of memory footprint, latency and energy consumption. Here we explore the deployment of 'mixture of experts' (MoEs) networks-networks that use conditional computing to keep computational demands low despite having many parameters-on three-dimensional (3D) non-volatile memory (NVM)-based analog in-memory computing (AIMC) hardware.

Delayed atorvastatin delivery promotes recovery after experimental spinal cord injury.

Spinal cord injury (SCI) significantly alters gene expression, potentially impeding functional recovery. This study investigated the effects of atorvastatin, a widely prescribed cholesterol-lowering drug, on gene expression and functional recovery in a chronic murine SCI model. Female C57BL/6J mice underwent moderate 0.

A 2D detector array for relative dosimetry and beam steering for FLASH radiotherapy with electrons.

Background: FLASH radiotherapy is an emerging treatment modality using ultra-high dose rate beams. Much effort has been made to develop suitable dosimeters for reference dosimetry, yet the spatial beam characteristics must also be characterized to enable computerized treatment planning, as well as quality control and service of a treatment delivery device. In conventional radiation therapy, this is commonly achieved by beam profile scans in a water phantom using a point detector.

Marginally outer trapped tubes in de Sitter spacetime.

We prove two results which are relevant for constructing marginally outer trapped tubes (MOTTs) in de Sitter spacetime. The first one (Theorem 1) holds more generally, namely for spacetimes satisfying the null convergence condition and containing a timelike conformal Killing vector with a "temporal function". We show that all marginally outer trapped surfaces (MOTSs) in such a spacetime are unstable.